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Selective multifaceted E3 ubiquitin ligases barricade extreme defense: Potential therapeutic targets for neurodegeneration and ageing

2015-11, Mishra, Amit Kumar

Efficient and regular performance of Ubiquitin Proteasome System and Autophagy continuously eliminate deleterious accumulation of nonnative protiens. In cellular quality control system, E3 ubiquitin ligases are significant employees for defense mechanism against abnormal toxic proteins. Few findings indicate that lack of functions of E3 ubiquitin ligases can be a causative factor of neurodevelopmental disorders, neurodegeneration, cancer and ageing. However, the detailed molecular pathomechanism implying E3 ubiquitin ligases in cellular functions in multifactorial disease conditions are not well understood. This article systematically represents the unique characteristics, molecular nature, and recent developments in the knowledge of neurobiological functions of few crucial E3 ubiquitin ligases. Here, we review recent literature on the roles of E6-AP, HRD1 and ITCH E3 ubiquitin ligases in the neuro-pathobiological mechanisms, with precise focus on the processes of neurodegeneration, and thereby propose new lines of potential targets for therapeutic interventions.

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Factors predicting infective complications following percutaneous nephrolithotomy and retrograde intrarenal surgery according to systemic inflammatory response syndrome and quick sequential organ failure assessment: A prospective study

2023-01-01, Mishra, Amit, Mittal, Jayesh, Tripathi, Sujata, Paul, Sourabh

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Butyrate inhibits HBV replication and HBV-induced hepatoma cell proliferation via modulating SIRT-1/Ac-p53 regulatory axis

2019-04-01, Pant, Kishor, Mishra, Amit K., Pradhan, Saman Man, Nayak, Baibaswata, Das, Prasenjit, Shalimar, Dr, Saraya, Anoop, Venugopal, Senthil K.

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Physiochemical Characterization of tubulin from Arachis hypogaea

2016-10-01, Harinipriya, S., Kalra, Aarat, Mishra, Amit K.

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Emergence of novel reassortant H6N2 avian influenza viruses in ducks in India

2018-07-01, Kumar, Manoj, Nagarajan, Shanmugasundaram, Murugkar, Harshad V., Saikia, Barnalee, Singh, Bharati, Mishra, Amit, Tripathi, Sushil K., Agarwal, Sonam, Shukla, Shweta, Kulkarni, Diwakar D., Singh, Vijendra Pal, Tosh, Chakradhar

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TGF-β induces liver fibrosis via miRNA-181amediated down regulation of augmenter of liver regeneration in hepatic stellate cells

2019-06-01, Gupta, Parul, Sata, Teja Naveen, Yadav, Ajay K., Mishra, Amit, Vats, Nisha, Musa Hossain, Md, Sanal, M. G., Venugopal, Senthil Kumar

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Protein nanocomposites: Special inferences to lysozyme based nanomaterials

2020-05-15, Sarkar, Sharanya, Gulati, Khushboo, Mishra, Amit, Poluri, Krishna Mohan

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Disturb mitochondrial associated proteostasis: Neurodegeneration and imperfect ageing

2023-01-01, Jagtap, Yuvraj Anandrao, Kumar, Prashant, Kinger, Sumit, Dubey, Ankur Rakesh, Choudhary, Akash, Gutti, Ravi Kumar, Singh, Sarika, Jha, Hem Chandra, Poluri, Krishna Mohan, Mishra, Amit

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Data on differential pathogenic ability of Helicobacter pylori isolated from distinct gastric niches

2023-04-01, Baral, Budhadev, Kashyap, Dharmendra, Varshney, Nidhi, Verma, Tarun Prakash, Jain, Ajay Kumar, Chatterji, Debi, Kumar, Vinod, Mishra, Amit, Kumar, Awanish, Jha, Hem Chandra

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Leukemoid reaction: A rare paraneoplastic event in a case of advanced penile cancer and its management

2019-08-01, Mishra, Amit Kumar, Mehra, Ketan, Manikandan, Ramanitharan, Dorairajan, Lalgudi Narayanan