Scalable organocatalytic one pot asymmetric Strecker reaction via camphor sulfonyl functionalized crown-ether-tethered calix[4]arene

Journal
Chemical Communications
ISSN
13597345
Date Issued
2024
Author(s)
Apoorva Malik
Kirti Antil
Nikhil Singh
Pragati R. Sharma
DOI
10.1039/d4cc02674h
Abstract
In this communication, we designed a highly selective camphor sulfonyl functionalized crown-ether-tethered calix[4]arene-derived organocatalyst for asymmetric Strecker reaction to provide the desired cyano adducts in high yields (∼99.9% yield) and enantioselectivities (up to 99.3% ee). Furthermore, 2 step facile syntheses of the antiplatelet drug (S)-clopidogrel exemplify the potential of this method for the preparation of commercial compounds.
Subjects