Terpenylation of Ketones and a Secondary Alcohol under Hydrogen-Borrowing Manganese Catalysis

Journal
The Journal of Organic Chemistry
ISSN
223263
Date Issued
2025-01
Author(s)
Sachin Jalwal
Sourajit Das
DOI
10.1021/acs.joc.4c02260
Abstract
An Earth-abundant Mn-PNP pincer complex-catalyzed terpenylation of cyclic and acyclic ketones and secondary alcohol 1-phenylethanol using isoprenoid derivatives prenol, nerol, phytol, solanesol, and E-farnesol as allyl surrogates is reported. The C-C coupling reactions are green and atom-economic, proceeding via dehydrogenation of alcohols following a hydrogen autotransfer methodology aided by metal-ligand cooperation. © 2024 American Chemical Society.
Subjects