Green pathway for the construction of aryl-1,8-naphthyridine-thiazole scaffolds and in vitro-antimicrobial evaluation, DNA binding interactions, viscosity measurements, molecular modeling studies and ADME properties

Ecofriendly approachable research can bring cost-effective technology; it is essential and desirable in the current state-of-the-art research. Green synthesis of substituted aryl-1,8-naphthyridine-thiazole-4-carboxamide derivatives and evaluation of their antibacterial and antifungal activity of all the synthesized compounds demonstrated remarkable in vitro microbial activity as well as DNA binding studies, and viscosity measurements by electronic absorption spectroscopy. The intrinsic binding constants (K b) values of (5a–f) molecules with Ct-DNA obtained from UV–Vis spectroscopy. Molecular docking studies results and ADME properties were well complemented to the DNA binding intercalative studies. Graphical abstract: [Figure not available: see fulltext.].